You need to make your best bets this week, so our friends at FanDuel ran all the numbers and are coming in hot with Week 15 NFL picks and predictions for the biggest games.
Week 14 of the 2022 season only brought us games on three different days of the week. What’s the deal with that? What even is that? Fortunately, the universe is about to sigh its magical sigh — we’re getting not one, but three Saturday NFL games well ahead of playoff time.
No more filibustering — we’re here to get fully hyped for another week in the league with the very best NFL predictions and picks for Week 15.
To get the slickest possible download, we buzzed our best friends at FanDuel for the complete breakdown based on the latest predictions for Seahawks, Dolphins, Commanders, and much more.
Check out Boardroom’s overview of the week’s most important games with our expert-curated Week 15 NFL predictions and picks below.
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2022 NFL Week 15 Predictions & Picks
49ers vs. Seahawks (Dec. 15)
Geno Smith has the Seahawks flying. The 49ers remain in pole position on the league’s longest win streak almost entirely irrespective of who they care to face. The NFC West continues to make no sense.
As Isaiah De Los Santos writes at TheDuel to kick off our Week 15 NFL predictions:
- 49ers: 47.3% to win
- Seahawks: 52.1% to win
This NFC West matchup should be a battle. Both offenses are full of playmakers, which could make this a potential shootout. However, San Francisco’s defense should help lead this team to another win, even against a strong Seahawks team.
The 49ers rank No. 1 in fewest points and yards allowed, so they have the personnel to quiet the likes of Geno Smith and the Seahawks offense. Seattle, meanwhile, ranks bottom five in both categories. All San Francisco needs is a fine showing from their quarterback, and they have a good chance of producing against this vulnerable Seahawks unit.
Seahawks vs. 49ers Prediction: Bet 49ers -1.5 (-110).
Colts vs. Vikings (Dec. 17)
Witness two teams having decidedly divergent seasons. The Colts are one of just five teams with 10+ wins entering the week despite being modest defensively and not overly explosive offensively, but while they could be an upset target in the postseason, we don’t really have high expectations about the Colts here and now.
As Isaiah De Los Santos writes at TheDuel:
- Colts: 26.3% to win
- Vikings: 73.4% to win
It’s hard to see the Colts having enough firepower to keep up in this one. Indy is No. 8 in fewest yards per game and No. 3 in fewest points, as this unit has struggled all year to produce. They’ve scored more than 20 points only twice in 13 games this season, which won’t get it done against the
